Kerbal Space Program

Recently, I was attempting to re-enter with a larger-than-designed portion of my rocket intact. At the exact moment I decided this was infeasible, and attempted to jettison the extra stage, the stage and its decoupler were destroyed by overheating. As a result, the spacebar press that was intended to activate the decoupler instead activated (and instantly destroyed) the drogue chutes on the stage behind it. Luckily, the drogues were not necessary for a low-altitude landing...

Before the staging rewrite, stages emptied of parts remained in the queue. This had many undesired consequences, but did not experience this problem.

Leaving this at Low priority because... well, if the precise timing of a spacebar press, relative to PART DESTRUCTION, during RE-ENTRY is critical to your rocket design, your rocket design is flawed. :)