Kerbal Space Program

Either Quicksave does not store the current target, or Quickload fails to restore it, but doing a Quicksave followed by a Quickload will forget your Target.

This is more important than it may look:

Just when you need it when learning to rendezvous and dock, the nice Quicksave function is useless. When two ships are in close proximity - and closing - after a Quickload there is no time to switch to map view, zoom in, and try to select one of the two ships that are very close together.

Recreated this on a completely fresh install (from Steam).